It is very common, the incidence has increased over time and there are scientifically well-established risk factors. Liver cancer is 5th most common cancer comprising 7% of all cancers and 2nd most frequent cause of cancer-related death globally(854,000 new cases and 810,000 deaths per year) HCC (hepatocellular carcinoma) accounts for approximately 90% of primary liver cancers. Between 1990 and 2015 newly diagnosed HCC cases increased by 75%, mainly due to changing age structures and population growth Cirrhosis precedes HCC in 80%-90% of patients, and one-third of all patients with cirrhosis will develop HCC. The incidence of HCC is 1%-8% per year in all patients with cirrhosis. The major causes of cirrhosis, and hence HCC are HBV, hepatitis C virus (HCV), alcohol (20-30% of HCC, heavy drinkers may not survive long enough to develop HCC thus underestimating risk), and nonalcoholic fatty liver disease.
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