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A specific type of cancer known as cholangiocarcinoma develops in the thin tubes (bile ducts) that transport the digesting fluid bile. The small intestine and the gallbladder are linked by bile ducts in the liver. Although it can happen at any age, cholangiocarcinoma, commonly known as bile duct cancer, mainly affects adults over the age of 50. Depending on where the cancer develops in the bile ducts, doctors categorize cholangiocarcinoma into many types: A kind of liver cancer known as intrahepatic cholangiocarcinoma develops in the bile ducts that are located inside the liver. Bile ducts nearby the liver are where the biliary cholangiocarcinoma of the liver develops. Additionally known as perihilar cholangiocarcinoma, this kind. A distal cholangiocarcinoma develops in the bile duct section closest to the small intestine. Additionally known as extrahepatic cholangiocarcinoma, this kind. Since cholangiocarcinoma is frequently discovered after cancer has spread, effective therapy might be challenging. When cells in the bile ducts have DNA alterations, cholangiocarcinoma develops. The instructions that inform a cell what to do are encoded in its DNA. The modifications instruct the cells to proliferate uncontrollably and aggregate into a mass of cells (tumor) that can infiltrate and damage healthy human tissue. It is unclear what alterations give rise to cholangiocarcinoma.
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